Mac's don't need defragging as OS X automatically writes 2Gb or below sized files to one contiguous space on the drive. There are certain cases where's it's needed to free up a large spaces on the drive, but not something everyone has to do. Speedup full title display for files in os x 10.13.
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Manual disk cleaning is not advisable for Mac users. There is a number of disk cleaning apps for Mac OS are available in Mac app store, it is hard to test and try every app available. To make it simple and easy I have chosen best and worth trying disk cleaning apps for Mac. List of Best Disk Cleaning Apps for Mac. Best Mac Cleaning App with Cache Cleaning. Developed by – Systweak Software. Version number – 1.5.5. File Size – 24 MB. Rating – macOS Compatibility – OS X 10.9 or higher. Trial Version – Yes. Money-Back Guarantee – 60-days. Systweak offers both.
Far as other Mac maintainence, there really isn't any except to backup one's files regularly. Keeping Software Updated and run a web browser check to make sure the plug-ins are current.
For Safari and Flash, this check is more accurate Samsung galaxy backup software for mac.
Best Mac Cleanup App
Most of those cleaning programs are junk, especially MacKeeper.
If your friend got onto your computer and visited a bunch of adult sites, then I would recommend something like OnyX, doing ALL the cleaning and maintenance aspects and rebooting, perhaps followed by a Disk Utility Erase free space.
Mac Cleaner App
CCleaner beta is out for OS X, used on PC's and combines cleaning and scrubbing of the drive if setup correctly.
Best Mac Cleaner App
If your interested in performance, read my post here